Combicox 20% - Technical Information

COMPARATIVE TOXICOLOGICAL STUDIES ON MONENSIN, SALINOMYCIN AND NARASIN IN FARM ANIMALS

Together with the wide application of polyether ionophore antibiotics as coccidiostats in broiler chickens (most often), as well as growth promoters in ruminants, they create quite a lot of toxicological problems in animal breeding. In scientific literature there have been described many cases of intoxication caused by them, which have resulted in enormous financial losses both in mammal breeding and poultry farming.

COMMISSION REGULATION (EC) No 156/2008 of 21 February 2008 amending Regulation (EC) No 109/2007 as regards the minimum content of the feed additive monensin sodium (EU version of Combicox®)

Having regard to Regulation (EC) No 1831/2003 of the European Parliament and of the Council of 22 September 2003 on additives for use in animal nutrition (1) and in particular Article 13(3) thereof.

COMMISSION REGULATION (EC) No 109/2007 of 5 February 2007 concerning the authorisation of monensin sodium (Coxidin) as a feed additive

Having regard to Regulation (EC) No 1831/2003 of the European Parliament and of the Council of 22 September 2003 on additives for use in animal nutrition (1), and in particular Article 9(2) thereof.

“Coxidin” the new monensin (EU version of Combicox®)

Alain Kanora DVM - Global Marketing Manager - Huvepharma

Evaluation of Production Performance and Residues in the Milk of Cows Fed Diets Supplemented with Sodium Monensin

In several countries ionophores have their use allowed in both beef cattle and dairy cattle. In countries like Brazil, Australia, New Zealand, Canada, United States and some European countries, the use of this product is permitted in dairy cows (Plazier et al., 2000; NRC, 2001; Simas & Nussio, 2001).

Evaluating the Quality of Antimicrobial or Anticoccidial products with Specific Reference to Monensin (Combicox®)

Companies selling antimicrobial or anticoccidial products base a lot of their claims on specific quality traits and whether a product is classified as non-generic or generic. Some of the claims are justified, but cannot be generalised across all product ranges. Company representatives are often dishonest by spreading false information about competitor products to the expense of the customer. Many times this represents misleading information and leaves incorrect perceptions with uninformed clients in the industry. To ensure that poultry and other livestock producers make sound decisions on what products to use a thorough understanding of what’s required to be a quality product backed by proper scientific evidence is needed.

Coxidin® 200 microGranulate (EU version of Combicox®)

Chicken Battery Study INRA (1999)

Coxidin® 200 microGranulate 2 (EU version of Combicox®)

INRA Floor Pen (2002)

Coxidin® 200 microGranulate 3 (EU version of Combicox®)

IRTA Floor Pen (2002)

Coxidin® 200 microGranulate 4 (EU version of Combicox®)

Broilers : Performance Floor Pen CLO (2003)

NUTRITIVE EFFECT OF BULGARIAN MONENSIN, SALINOMYCIN AND NARASIN IN LAMBS FOR FATTENING

There are plenty of publications in literature about the nutritive effect of monensin in ruminants [2, 3, 4, 6, 8, 9], and the mechanism of its probiotic function in the pre-rumen has been completely clarified. Significantly less in number are the studies on the stimulating effect of salinomycin. So are the studies on narasin. There are no sufficient comparative data with respect to the nutritive effect of monensin, salinomycin and narasin, as well as to sex-dependent differences.

COMPARATIVE TOXICOLOGICAL STUDIES ON MONENSIN, SALINOMYCIN AND NARASIN IN FARM ANIMALS

Together with the wide application of polyether (ionophore) antibiotics) as coccidiostats in broiler chickens (most often), as well as growth promoters in ruminants, they create quite a lot toxicological problems in animal breeding. In scientific literature there have been described many cases of intoxication caused by them, which have resulted in enormous financial losses both in mammal breeding and poultry farming. From the conducted trials it becomes clear that the toxicological hazards caused by the application of polyether antibiotics depend on the type of the preparation, as well as on animal species, their age, sex, and the ration composition they are fed on.

Combicox 20% Granular Premix (Monensin Sodium)

Coxidin® 200 microGranulate

Compare the content of monensin 20% in the different particles categories of two BSA registered Feed additive available.

Combicox 20% Granular Premix (Monensin Sodium)

Die veilige en doeltreffende gebruik van antibiotiese groeistimulante met speifieke verwysing na herkouers

Antibiotikas is nie net belangrike vir die behandeling van bakteriese siektetoestande by mense nie, maar vervul ook ʼn baie belangrike rol in die doeltreffende produksie van voedsel soos eiers, melk en vleis. Toegedien teen hoër konsentrasies is antibiotikas grootliks onontbeerlik vir die voorkoming, beheer en behandeling van sekere siektetoestande.

Ionophores in dairy penn2005-duffield

Ionophores have been used extensively in the beef industry in Canada since 1977. Until recently, there has been no label indication for use of phores in lactating dairy cattle. Ionophores are feed additives that alter rumen microbial populations through ion transfer across cell membranes. In Canada, the label warning prohibiting the use of Rumensin premix in lactating dairy cattle was removed in June 1996.